The blood-grouping reagents market is set to witness a significant expansion, projected to increase by USD 611.8 million from 2024 to 2029, at an impressive CAGR of 8.8%, according to the latest industry data. As chronic illnesses become increasingly prevalent and diagnostic technologies continue to evolve, the need for fast, reliable blood typing and transfusion compatibility testing is driving demand across healthcare systems globally.For more details about the industry, get the PDF sample report for free
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Blood-grouping reagents are critical tools used in laboratories, hospitals, and blood banks to determine the ABO and Rh compatibility of blood samples. These reagents facilitate safe blood transfusions, transplantation procedures, and even prenatal diagnostics.
They are applied in:
Cross-matching tests
Antibody screening for red blood cells
Inventory management in blood banks
Typing and matching during surgeries and cancer treatments
The growing frequency of blood transfusions required for cancer, cardiac disease, and trauma care—particularly in aging populations—is pushing demand for innovative reagent-based solutions.
The blood-grouping reagents industry features a competitive landscape with both established diagnostics leaders and emerging innovators. Companies are expanding their portfolios through R&D, M&A, and strategic collaborations.
Ortho Clinical Diagnostics
Thermo Fisher Scientific Inc.
Bio-Rad Laboratories Inc.
Grifols SA
AliveDx – Notably offering ALBAclone Anti A/B/D reagents
Danaher Corp.
Arena BioScience
Fortress Diagnostics
Atlas Medical GmbH
Tulip Diagnostics Pvt. Ltd.
These firms offer a range of serological and molecular blood-grouping products and are pioneering the shift toward automated systems, rapid test kits, and point-of-care diagnostics.
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The market is segmented by product type, technique, and end-user, with each playing a pivotal role in clinical and research settings.
Anti-sera reagents
Red blood cell reagents
Blood bank saline
Others
PCR-based and Microarray
Assay-Based Techniques
Massively Parallel Sequencing
Traditional Serology
Hospitals and Blood Banks – The largest segment
Clinical Laboratories
Academic and Research Institutes
Rising prevalence of chronic diseases like cancer, cardiovascular disease, and diabetes
Growing need for safe transfusions during surgical and emergency care
Demand from aging populations with increased medical needs
In the US alone, 1.96 million new cancer cases were reported in 2023, driving unprecedented demand for compatible blood supplies and advanced typing methods.
Molecular Blood Grouping: Identifies polymorphisms and reduces transfusion complications
AI & Automation: Enhances diagnostic accuracy and reduces turnaround time
Point-of-care Testing: Useful in resource-limited or rural settings
HLA Typing and Next-Gen Sequencing: Being integrated into clinical protocols for transplants
These developments are reshaping how healthcare facilities approach blood diagnostics, pushing the market toward faster, more scalable, and less error-prone solutions.
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High incidence of invasive cancer (29+ million cases since 2003)
Extensive network of blood banks and hospitals
Government support for diagnostic infrastructure
Increased surgical volumes, organ transplant procedures, and a growing geriatric population are also driving consistent demand for blood typing and matching systems.
Europe – Strong growth in France, Germany, Italy, and the UK with widespread adoption of serology and molecular techniques.
Asia-Pacific – Fastest-growing region due to rising healthcare investments and expanding diagnostic capabilities in India and China.
Rest of the World (ROW) – Includes emerging markets adopting rapid blood typing technologies for rural healthcare.
Rising global surgical volumes and emergency care infrastructure
Expansion of research applications using blood-grouping reagents
Integration of digital diagnostic platforms in hospital labs
Growing interest in personalized medicine and genotypic typing
Transfusion Risks: Hemolytic reactions, allergies, and fever due to blood-type mismatches
Cost of Advanced Equipment: May limit adoption in lower-income regions
Regulatory Approvals: Complex and time-consuming for new diagnostic reagents
Despite these barriers, industry players are investing heavily in education, training, and regulatory navigation to ensure product accessibility and safety.
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The Blood-Grouping Reagents Market is experiencing substantial growth driven by increasing demand for accurate blood typing reagents and blood grouping reagents used in healthcare settings to ensure blood safety. Rising awareness of blood transfusion risks and the importance of blood compatibility have led to expanded adoption of ABO typing, Rh typing, and antigen detection procedures globally. The market is significantly supported by the use of reagent kits, monoclonal antibodies, and antisera reagents in serology tests to prevent hemolytic reactions and improve the reliability of blood bank testing. Applications in blood donation centers and hospitals include cross-match testing, slide test, and tube test methodologies using phenotyping reagents and blood typing systems for identifying blood group antigens. Additionally, innovations in automated systems and rapid test kits are streamlining point-of-care testing, while the integration of microplate technology, gel cards, and diagnostic reagents continues to modernize traditional immunohematology procedures.
2025 Forecast: Market growth of USD 611.8 million, led by automation and chronic disease burden
Who should care? Diagnostic labs, hospital administrators, blood banks, biotech investors
What’s new? Molecular typing, sequencing, and AI-driven diagnostics
Where’s the growth? Primarily in North America, followed by Asia-Pacific and Europe
Why now? Chronic diseases, aging population, and rapid technology adoption
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CAGR: 8.8%
Top Segment: Hospitals and Blood Banks
Top Region: North America
Top Techniques: PCR, Assay-Based, Sequencing
Key Demand Drivers: Cancer, Cardiac, Emergency Surgeries
Analytical advancements in the Blood-Grouping Reagents Market are being driven by molecular innovations such as PCR-based techniques, microarray techniques, and assay-based techniques, which complement conventional hematology testing practices. Technologies like massively parallel sequencing are being explored for high-throughput identification of rare blood types, critical for recipient profiling and managing chronic disorders. Enhanced donor screening protocols using reagent controls ensure accurate blood matching and minimize transfusion reactions. Research is increasingly focused on refining molecular tests to support robust blood inventory management and paper-based assays are gaining traction for use in low-resource settings. Furthermore, next-gen blood typing systems support detailed analyses and enable decentralized testing, contributing to the growth of the global market. The emphasis on advanced tools for diagnostic reagents and point-of-care testing continues to accelerate innovations and ensure compatibility across a wide spectrum of transfusion-related scenarios
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